Whey protein taken with vitamins C, E may reduce CKD inflammation
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Key takeaways:
- Results indicated a significant decrease in interleukin-10 levels after 8 weeks.
- IL-6 decreased by 810.95% during the same period.
Whey protein combined with vitamins C and E may significantly reduce inflammation in patients with chronic kidney disease on hemodialysis, according to published data.
“Chronic inflammation and malnutrition are commonly seen in patients with CKD,” Angela Teodósio da Silva, of the department of nutrition at the Federal University of Santa Catarina in Brazil, and colleagues wrote. “The recommended intake of protein and other nutrients may be compromised due to anorexia, resulting from uremia. Whey protein demonstrates antioxidant and anti-inflammatory properties. Our hypothesis was that combined supplementation could decrease inflammatory markers.”
Researchers used a pioneering, double-blind pilot study to analyze patients in a hospital dialysis unit from January to March 2020. In the placebo-controlled clinical trial, 23 patients were categorized into two groups and stratified by frequency of hemodialysis (HD).
The supplementation group received 20 g of whey protein, 250 mg of vitamin C and 600 IU of vitamin E. Patients in the placebo group were given 20 g of rice flour and microcrystalline cellulose capsules. The interventions were administered after hemodialysis, three times a week, for 8 weeks. Researchers assessed several inflammatory markers, including interleukin (IL)-12p70, IL-10, IL-6, IL-8 and tumor necrosis factor-alpha, using a series of tests to examine statistical analysis.
Results showed no significant differences in inflammatory markers between the groups after the intervention. Within the supplementation group, there was a significant decrease in IL-10 after 8 weeks, according to study results. IL-6 decreased by 810.95% in the supplementation group, while it increased 732.8% among the placebo group, the authors wrote.
“Whey protein combined with vitamins C and E significantly reduced IL-10 in the supplementation group and could be beneficial to reduce IL-6 in HD patients,” Teodósio da Silva and colleagues wrote. “Future studies are suggested with a larger sample size, different supplementation doses and longer interventions.”
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