Lifestyle interventions show positive effect on CKD progression, quality of life
Click Here to Manage Email Alerts
Key takeaways:
- Lifestyle interventions improved creatinine measures.
- The interventions did not impact eGFR.
Lifestyle interventions improved measures for creatinine, 24-hour albuminuria, blood pressure and body weight among patients with chronic kidney disease, according to data published in Kidney Medicine.
“Strategies to prevent the development and progression of CKD are important. Lifestyle-related factors, such as increasing intake of vegetables, increasing physical activity, reducing salt intake and moderating alcohol consumption, are associated with primary prevention of CKD,” Elizabeth P. Neale, PhD, from University of Wollongong, and colleagues wrote. They added, “[T]he effects on progression and quality of life (QoL) are yet to be synthesized fully. We sought to undertake a systematic review of lifestyle interventions on the risk factors for and progression of kidney disease and QoL in people with CKD.”
In a systematic review and meta-analysis, researchers examined 78 records that described 68 studies. Of these studies, 24 were dietary interventions, 23 were exercise interventions, nine were behavioral interventions, one was a hydration intervention and 11 included several components of these methods.
All included patients who were aged at least 16 years with CKD who did not require kidney replacement therapy.
Researchers collected data regarding kidney function, albuminuria, creatinine, systolic blood pressure, diastolic blood pressure, body weight, glucose control and QoL. Using GRADEpro GDT: GRADEpro Guideline Development Tool, researchers measured the certainty of the body of evidence.
“[T]he quality of the evidence base is very low, and further synthesis, such as outcomes relating to QoL, are limited by variations in the measurements used,” Neale and colleagues wrote. “Future studies with more robust designs are needed that are also guided by outcomes important to patients and are of longer duration.”
Analyses revealed lifestyle interventions led to significant improvements in creatinine, 24-hour albuminuria, systolic blood pressure, diastolic blood pressure and body weight measures. However, these changes were not seen in eGFR.
“Identifying successful lifestyle interventions in CKD can guide future clinical practice. When studies were separated according to type of intervention, findings varied between outcomes,” Neale and colleagues wrote. “Although results should be interpreted with caution due to variation in the number of studies within each subgroup, exercise interventions appeared to result in the greatest improvements in eGFR and creatinine, although dietary interventions resulted in large improvements in albuminuria and systolic blood pressure.”
Collapse
Read more about
Click Here to Manage Email Alerts