1 in 20 adult outpatients hospitalized after RSV diagnosis
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Key takeaways:
- One in 20 patients with medically attended RSV infections required hospitalization.
- Hospitalization prevalences were increased among older patients and patients with asthma, COPD or congestive heart failure.
Among outpatients with respiratory syncytial virus, one in 20 experienced all-cause hospitalization, according to a recent study.
“In the United States, there are currently limited estimates that exist to determine the risk of hospitalization following outpatient RSV disease diagnoses,” Joshua T. Swan, PharmD, MPH, senior director and category clinician in Internal Medicine and Infectious Disease Development at Pfizer Inc., told Healio.
“Therefore, this study was conducted to address this gap in the literature and inform development of clinical trials that will assess efficacy of an outpatient RSV antiviral treatment in preventing RSV-related hospitalization within 28 days among adults with high risk of progression to severe illness,” he said.
Swan and colleagues conducted a cohort study using data from three different databases —
Integrated Claims-Clinical, TriNextX Linked and Veradigm Network EHR. Data included in the analysis were from electronic health records of adults with RSV-specific diagnosis codes across six RSV seasons between Oct. 1, 2016, and Sept. 30, 2022.
According to the study, the primary outcome was all-cause 28-day hospitalization following medically attended RSV infections among all adult outpatients and among a high-risk subgroup of adult outpatients, including patients aged 65 years and older and those with asthma, chronic obstructive pulmonary disease (COPD), or congestive heart failure (CHF).
Overall, the study showed that one in 20 of the 67,239 adults included in the study experienced all-cause hospitalization within 28 days.
Data from the high-risk study population revealed all-cause hospitalization prevalences of 20% to 30.5% for patients with COPD, 14.6% to 24.4% for patients with CHF, 14.6% to 24.4% for patients with asthma and 14% to 54.5% for patients aged 65 years or older.
Based on these data, Swan concluded that the results “highlight the unmet medical need for outpatient interventions and preventive measures that can reduce hospitalizations.”
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