Diabetes linked to poorer survival after nephrectomy for renal cell carcinoma
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Key takeaways:
- Patients with diabetes achieved shorter OS than those without diabetes.
- Other predictors of shorter survival included male sex and older age.
NASHVILLE, Tenn. — Diabetes appeared linked to shorter survival among patients who underwent nephrectomy for renal cell carcinoma, according to study results presented at International Kidney Cancer Symposium: North America.
The findings highlight the need for differentiated treatment and monitoring for this population, researchers concluded.
“Future studies should investigate both the combined and separate impact of diabetes mellitus and nephrectomy on OS, and explore alternative surgical techniques, conservative treatments and additional outcome measures to optimize care,” Emma Heeno of the department of urology at Odense University Hospital in Denmark and colleagues wrote.
Prior studies have assessed the association between diabetes mellitus and survival among patients who underwent nephrectomy for renal cell carcinoma. However, the findings from these investigations have been inconsistent, according to study background.
Heeno and colleagues used Danish Cancer Registry data to assess the effect of diabetes on OS among individuals with renal cell carcinoma who underwent nephrectomy.
The observational, retrospective register-based cohort study included 6,198 patients with renal cell carcinoma who underwent nephrectomy between 2000 and 2018 at hospitals in Denmark.
Researchers divided patients into two groups based on pre-surgery diabetes status (yes, 12.5%; no, 87.5%).
Patients who had diabetes prior to surgery exhibited a greater risk for death (HR for OS = 1.36; P < .001).
Male sex also appeared associated with higher risk for death (HR = 1.11; P = .015). OS outcomes worsened with age. Compared with patients aged younger than 60 years, results showed elevated risk for death among those aged 60 to 69 years (HR = 1.44; P < .001), 70 to 80 years (HR = 1.98; P < .001) and older than 80 years (HR = 2.86; P < .001).
Researchers also reported significant associations between tumor, node and metastasis stages and poorer survival.
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Heeno E, et al. Abstract 63. Presented at: IKCS: North America; Nov. 9-11, 2023; Nashville, Tenn.
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