VIDEO: AML diagnoses increase as general population ages

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Currently we're seeing an increase in the number of patients being diagnosed with acute myeloid leukemia largely because the general population is aging and obviously individuals are not dying of cardiac disease or infectious disease as much as they were in the past, and, in general, we're all getting a little bit grayer and a little bit older. However, we are seeing that our colleagues in the solid-tumor world are getting better and better at treating and keeping their patients alive, and with subsequent therapies, including multiple lines of therapy, we're seeing an incidence rise in the number of patients developing therapy-related AML.

Our new data suggests that patients who have clonal hematopoiesis or baseline germline mutations acquired over time or inherited through their families are also at higher risk. So I think with our increased diagnostics, increased awareness, detection of early mutations, as well as patients living longer and having additional therapies, the incidence of AML continues to rise.