New approach needed to manage adults with colorectal cancer, fatty liver
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Proteins and genetic material secreted by fatty liver cells stimulate the spread of colorectal cancer to the liver, study results published in Cell Metabolism showed.
An international group of researchers conducted a series of preclinical analyses describing a process by which extracellular vesicles released by fatty liver cells occurred in mice fed a high-fat diet.
These cells contain types of RNA that react with another protein — the Yes-associated protein — to promote aggressive cancer that is more likely to metastasize.
The investigators confirmed the existence of the same process occurring in human tissue samples from patients with colorectal cancer who had liver metastases.
Healio spoke with Ekihiro Seki, MD, PhD — professor of medicine and biomedical sciences at Cedars-Sinai — about the results, and why a new approach for management of adults with colorectal cancer and fatty liver may be required.
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