VIDEO: Potential in-utero transfer of stem cells may impact future MPN research
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In this video, Brynn H. Parsegov, PA-C, discussed a case of fraternal female twins who sequentially presented with JAK2V617F mutation-positive myeloproliferative neoplasms.
The case study was presented at the 14th International Congress on Myeloproliferative Neoplasms.
“We think that this happened in utero,” Parsegov, physician assistant in the division of hematology and hematologic malignancies at University of Utah’s Huntsman Cancer Institute, said.
She also noted that while both patients have the phenotype for essential thrombocythemia, one has progressed to myelofibrosis.
“It’s going to open the door for future research into looking [at] how these diseases are going to impact families, and twins specifically, via this mechanism,” Parsegov said.
Reference:
- Parsegov BH. Dizygotic twins with JAK2V617F mutation positive myeloproliferative neoplasms arising from a potential chimerism occurring through placental anastomoses. Presented at: 14th International Congress on Myeloproliferative Neoplasms; Oct. 27-28, 2022; Brooklyn, New York.
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