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Hip fractures double mortality risk in type 2 diabetes
Japanese adults with type 2 diabetes were more than twice as likely to die of any cause in the 5 years after experiencing a hip fracture when compared with similar adults who did not sustain a hip fracture, according to findings published in the Journal of Diabetes Investigation.
“A better understanding of geriatrics is required in the clinical management of patients with diabetes,” Masanori Iwase, MD, PhD, of the department of medicine and clinical science in the Graduate School of Medical Sciences at Kyushu University in Fukuoka, Japan, and colleagues wrote. “Few studies have investigated the impact of hip fractures on the risk of death in patients with type 2 diabetes who also have a higher prevalence of fatal diseases, such as cardiovascular disease, renal disease or malignant neoplasia.”
During a median of 5.3 years, Iwase and colleagues collected data on events of death, hip fracture, CVD and end-stage renal disease from yearly questionnaires as well as medical and municipal records of 4,923 adults with type 2 diabetes from the Fukuoka Diabetes Registry (mean age, 65 years; 43.3% women). Hip fractures were reported by 110 participants and upper limb fractures were reported by 801 participants. According to the researchers, there were 1,344 cases of CVD and 104 cases of ESRD.
The researchers found that participants who had a hip fracture were at increased risk for all-cause mortality compared with participants without such a fracture (OR = 2.67; 95% CI, 1.54-4.41), with the researchers noting that this finding persisted when adjusting for CVD and ESRD (OR = 2.74; 95% CI, 1.58-4.54). Forty percent of the deaths in the group that had a hip fracture occurred due to infection and 25% occurred due to malignancy. Participants who sustained a hip fracture were more likely to die due to infection vs. those without a hip fracture (P = .03), according to the researchers.
“It should be emphasized that hip fracture is a critical event in the aging population of patients with type 2 diabetes during the present era of a better prognosis of CVD,” the researchers wrote. “In addition, whether prevention of hip fracture might improve the survival of patients with type 2 diabetes remains to be determined.” – by Phil Neuffer
Disclosures: The authors report no relevant financial disclosures.