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Urinary glucose excretion can alter uric acid levels, hyperuricemia development
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Adults with diabetes and an elevated rate of urinary glucose excretion may have lower serum uric acid levels and be less likely to develop hyperuricemia, according to findings published in Diabetic Medicine.
“The effect of hyperuricemia on health and disease cannot be ignored. In addition to gout, hyperuricemia plays a significant role in the development of dyslipidemia, hypertension, diabetes mellitus and renal disease,” Zilin Sun, MD, PhD, of the department of endocrinology at Zhongda Hospital, Institute of Diabetes, School of Medicine, Southeast University, in Nanjing, China, and colleagues wrote. “Therefore, assessment of factors affecting uric acid levels in the blood may be particularly important for early disease prevention and improvement in health outcomes.”
Sun and colleagues conducted a cross-sectional study of data from 597 adults who had recently been diagnosed with diabetes. Participants were divided into groups based on low urinary glucose excretion of less than 130 mg (n = 142; 68.3% women; mean age, 51.02 years) and high urinary glucose excretion of more than 130 mg (n = 455; 45.7% women; mean age, 49.63 years).
Hyperuricemia was confirmed in men with serum uric acid levels of more than 416 µmol/L and in women with levels of more than 357 µmol/L. Of the total cohort, 21.4% met these requirements for the condition, which was observed in 28.9% of those with low urinary glucose excretion and 19.1% of those with high urinary glucose excretion (P = .019). Similarly, participants with high urinary glucose excretion were less likely to develop hyperuricemia (OR = 0.47; 95% CI, 0.27-0.8).
The researchers also found a negative association between urinary glucose excretion and serum uric acid levels both in men (P < .001) and women (P < .028). This association held in adjusted models (P = .002), which included adjustments for sex, age, fasting plasma glucose and total cholesterol, among other factors.
“The results suggest that, in addition to lowering blood glucose, promoting [urinary glucose excretion] may also be an effective approach to reducing the levels of uric acid in blood, especially for people with diabetes complicated with hyperuricemia,” the researchers wrote. – by Phil Neuffer
Disclosures: The authors report no relevant financial disclosures.
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