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MrOS: Vertebral fracture rates comparable in people with, without diabetes
The prevalence and incidence of vertebral fractures do not appear to be higher in adults with type 2 diabetes than in adults without diabetes; however, greater spine areal bone mineral density may be associated with a lower risk among both groups, study data show.
Nicola Napoli, MD, PhD, of the unit of endocrinology and diabetes, department of medicine at the Universitá Campus Bio-Medico di Roma in Italy, and colleagues evaluated data from the Osteoporotic Fractures in Men study (MrOS) on 5,554 men (mean age, 73.6 years) with (n = 875) or without type 2 diabetes to determine whether the prevalence and incidence of vertebral fractures are higher in those with diabetes. Two percent of participants without diabetes and 2.2% with diabetes were prescribed anti-osteoporosis treatment.
Overall, 7% of participants with diabetes and 7.7% without diabetes had prevalent vertebral fractures, and 4.4% of participants with diabetes and 4.5% without diabetes had incident vertebral fractures.
The estimated association between diabetes and vertebral fractures increased after adjustment for areal BMD (OR = 1.05; 95% CI, 0.78-1.4) and volumetric BMD (OR = 1.3; 95% CI, 0.89-1.88); however, the increases did not reach statistical significance. No difference was found between the two groups for risk for incident vertebral fractures.
A lower risk for prevalent vertebral fracture was associated with higher spine areal BMD in participants with diabetes (OR = 0.55; 95% CI, 0.48-0.63) and without diabetes (OR = 0.66; 95% CI, 0.5-0.88); the risk for incident vertebral fracture was also lower with higher spine areal BMD in diabetes (OR = 0.5; 95% CI, 0.41-0.6) and no diabetes (OR = 0.54; 95% CI, 0.33-0.88). Similar results were observed for volumetric BMD. – by Amber Cox
Disclosures: The researchers report no relevant financial disclosures.