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Age, BMI tied to diabetes, MI, stroke risk
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Adults with impaired fasting glucose are at risk for development of type 2 diabetes, acute myocardial infarction and stroke within the first 5 years of diagnosis, and the risk is increased among those aged 40 to 49 years and those with high BMI, study data show.
Dennis Bingzhu Chia, MPH, MBBS, of the National Healthcare Group in Singapore, and colleagues evaluated data from the hospitals and primary care clinics on 2,295 adults with newly diagnosed IFG to determine the incidence and predictive factors for development of type 2 diabetes, acute MI and stroke during a 5-year period.
Overall, 24.1% of participants developed one of the outcomes; 21.4% developed type 2 diabetes, 2.7% developed stroke and 0.9% developed acute MI.
Race (P = .012), age (P < .001), levels of HDL cholesterol (P < .001), blood pressure (P = .002) and BMI (P < .001) were all associated with the development of type 2 diabetes, acute MI and stroke. Participants aged 40 to 49 years had a higher risk for development compared with those aged 70 to 79 years (adjusted OR = 2.25; 95% CI, 1.44-3.51), as well as those with BP of at least 140/90 mm Hg (aOR = 1.62; 95% CI, 1.26-2.1) and BMI of at least 27 kg/m2 (aOR = 2.35; 95% CI, 1.61-3.41) after adjustment for possible confounders in the multivariate model.
Sex (P = .028), race (P = .007), age (P < .001), levels of HDL (P < .001), BP (P = .011) and BMI (P < .001) were all associated with the development of type 2 diabetes. Predictors of type 2 diabetes were being female (aOR = 1.43; 95% CI, 1.1-1.85), those aged 40 to 49 years (aOR = 3.23; 95% CI, 2.01-5.21), BP of at least 140/90 mm Hg (aOR = 1.57; 95% CI, 1.2-2.05) and BMI of at least 27.5 kg/m2 (aOR = 2.33; 95% CI, 1.96-3.46).
The development of acute MI was higher among men compared with women (1.4% vs. 0.5%; P = .021) and those with a history of chronic kidney disease (P < .001).
The development of stroke was associated with differences in age (P < .001), history of hyperlipidemia (P = .018) and history of CKD (P = .007).
According to the researchers, reducing the interval for screening for individuals with normal screening results may help prevent development of type 2 diabetes, acute MI and stroke. – by Amber Cox
Disclosures: The authors report no relevant financial disclosures.
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