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History of PCOS in gestational diabetes tied to incident diabetes
Women with gestational diabetes and a history of polycystic ovary syndrome have an increased risk for incident diabetes compared with women without gestational diabetes, study data show.
Kaberi Dasgupta, MD, MSc, FRCPC, associate professor in the department of medicine at McGill University in Montreal, and colleagues evaluated data from the Quebec Physician Services Claims, Hospitalization Discharge Databases, and birth and death registries on 34,686 women with gestational diabetes during pregnancy matched to women without gestational diabetes. Researchers sought to determine whether PCOS increases the risk for incident diabetes after gestational diabetes, as well as to explore the relationships between PCOS and incident diabetes when women did not have gestational diabetes. Mean follow-up was 12.5 years.
Overall, PCOS was present in 1.5% of participants with gestational diabetes and 1.2% without gestational diabetes. Overall, diabetes incidence was 12.75 per 1,000 person-years among participants with PCO and 7.59 per 1,000 person-years among participants without PCOS.
The incident diabetes rate was higher in participants with gestational diabetes and PCOS (24.85 per 1,000 person-years) than participants with gestational diabetes without PCOS (14.92 per 1,000 person-years).
PCOS was significantly associated with incident diabetes in participants with a history of gestational diabetes (HR = 1.64; 95% CI, 1.38-1.95) but not in participants without a history of gestational diabetes.
Incident diabetes in women with gestational diabetes was associated with older age, not being of white ancestry, pulmonary disease and psychiatric disease.
“The present results suggest that PCOS is an independent risk factor for diabetes in fertile women with [gestational diabetes],” the researchers wrote. “We believe this study supports the need for intensive screening, education, close follow-up and risk factor reduction postpartum in the PCOS population who develop [gestational diabetes].” – by Amber Cox
Disclosures: The authors report no relevant financial disclosures.