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Vitamin D3 supplementation fails to affect thyroid autoimmunity
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Thyroid autoimmunity or status was not affected by vitamin D3 supplementation compared with placebo after 16 weeks in apparently healthy adults, according to findings published in the Journal of the Endocrine Society.
Kirsten V. Knutsen, of the department of general practice, Institute of Health and Society at the University of Oslo in Norway, and colleagues evaluated adults aged 18 to 50 years with South Asian, Middle Eastern or African backgrounds randomly assigned to daily supplementation with 25 µg vitamin D3 (n = 83), 10 µg vitamin D3 (n = 85) or placebo (n = 82) for 16 weeks. Researchers sought to determine the effect of vitamin D3 compared with placebo on thyroid autoantibodies.
Researchers observed no significant effect on antithyroid peroxidase antibody (TPOAb), thyroid-stimulating hormone or free thyroxine after 6 weeks of vitamin D3 supplementation compared with placebo. The effect did not change after adjustment for age, sex and baseline level of vitamin D3. At baseline, 51% of participants had TPOAb levels less than 50 kU/L. After 16 weeks of treatment, 36% of participants had TPOAb levels less than 50 kU/L (P < .001); however, no difference was found between participants assigned to vitamin D3 or placebo.
‘The use of 16 weeks of daily vitamin D3 supplementation (25 µg per day or 10 µg per day) showed no significant effect on thyroid autoimmunity or status compared to placebo in this study among adult, presumed health study participants from ethnic minorities living in Norway,” the researchers wrote. “The trial had a high prevalence of participants with serum 25-(OH)D3 < 50 nmol/L at baseline.” – by Amber Cox
Disclosure: The researchers report no relevant financial disclosures.
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