This article is more than 5 years old. Information may no longer be current.
Low-dose aspirin fails to affect menstrual cycles
Click Here to Manage Email Alerts
The risk for anovulation is not significantly increased by low-dose aspirin in women with a history of one or two pregnancy losses, study data show.
Enrique F. Schisterman, PhD, chief and senior investigator, epidemiology branch division on intramural population health research at Eunice Kennedy Shriver National Institute of Child Health and Human Development of the NIH, and colleagues evaluated data from the Effects of Aspirin in Gestation and Reproduction trial on 1,214 healthy women (mean age, 28.8 years) with regular menstrual cycles attempting pregnancy. Participants had a history of one to two pregnancy losses and two or fewer live births and were fertile.
Participants were assigned to 81 mg aspirin daily for one to six menstrual cycles. At least one menstrual cycle of follow-up was completed by all participants.
Overall, anovulation occurred in 12.2% of 4,340 menstrual cycles. The occurrence of anovulation was not affected by low-dose aspirin (low-dose aspirin, 13.4% vs. placebo, 11.1%; RR = 1.16; 95% CI, 0.88-1.52).
“[Low-dose aspirin] did not affect sporadic anovulation among regularly cycling women with a history of one to two pregnancy losses in a randomized controlled trial,” the researchers wrote. “These findings clarify that ovulation was not the reproductive event affected by [low-dose aspirin] to increase pregnancy and live birth among women who were attempting to conceive spontaneously after a single recent loss. Possible effects of [low-dose aspirin] to improve tubal transport of the gametes and embryo, embryonic development and implantation merit further study.” – by Amber Cox
Disclosure: The researchers report no relevant financial disclosures.
Click Here to Manage Email Alerts