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BMD z scores similar in hypogonadotropic, hypergonadotropic hypogonadism
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Adolescent girls with hypogonadotropic and hypergonadotropic hypogonadism had similar low bone mineral density z scores, which did not appear to be clinically affected by follicle-stimulating hormone levels, recently published data show.
Hüseyin Demirbilek, MD, of the Clinic of Pediatric Endocrinology at Diyarbakir Children State Hospital in Turkey, and colleagues evaluated 33 girls with hypogonadism (hypogonadotropic hypogonadism, n = 14; hypergonadotropic hypogonadism, n = 19) to determine BMD and to investigate the correlation between follicle-stimulating hormone (FSH) level and BMD. Researchers measured FSH, luteinizing hormone and estradiol levels and BMD by DXA.
Low BMD z scores (< 2 standard deviation) were similarly found in both groups (71.4% of the hypogonadotropic group vs. 89.5% of the hypergonadotropic group). After adjustment for height, low BMD z scores were still similar in both groups (21.4% hypogonadotropic group vs. 15.8% hypergonadotropic group). No significant difference was found between the two groups for BMD z score measures from the spine and femur neck.
In the hypergonadotropic group, researchers observed no association between FSH level and height-adjusted BMD z score measured from the spine, but there was a moderate positive association with height standard deviation score and a moderate negative association with gonadotropin for BMD measured from the femur.
“This study, which evaluated BMD in adolescent girls with hypogonadotropic and hypergonadotropic hypogonadism, revealed a low BMD z score in the majority of cases in both groups,” the researchers wrote. “However, when adjusted for height, a marked improvement was observed, particularly in BMD z scores of the hypergonadotropic group. FSH level was not found as an independent factor affecting BMD z score. The negative correlation between FSH and BMD z score measured from the femur neck was attributed to the more severe estrogen deficiency.” – by Amber Cox
Disclosure: The researchers report no relevant financial disclosures.
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