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Obesity linked with increased inflammatory markers in type 2 diabetes

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ORLANDO, Fla. — High sensitivity C-reactive protein levels and white blood cell counts are increased in patients with type 2 diabetes and obesity, according to study findings presented here.

No correlation was found between obesity and HbA1c level.

In a cross-sectional study, David Soyoye, MBChB, FMCP, of Obafemi Awolowo University in Ife, Nigeria, and colleagues evaluated data from 155 patients with type 2 diabetes (66 men; mean age, 56.5 years) from a diabetes clinic to determine relationships among obesity, HbA1c level and inflammatory markers.

Mean BMI was 25.8 kg/m² in men and 29.2 in women kg/m²; 23.3% had BMI greater than 30 kg/m². Mean waist circumference was 93.2 cm in men and 97.5 cm in women; 75.8% of the cohort had increased waist circumference (> 94 cm in men, > 80 cm in women). Mean HbA1c was 7.99% in men and 7.88% in women; mean total white blood cell count was 5.99 x 10³ mm³ in men and 5.83 x 10³ mm³ in women; mean hs-CRP was 1.23 mg/L in men and 1.68 mg/L in women.

Waist circumference was correlated with white blood cell count (P = .024), and BMI was correlated with white blood cell count (P = .022) and hs-CRP (P = .028), but neither obesity marker was linked to HbA1c.

“Our study showed significant correlation between [obesity and total white blood cell count] and hs-CRP, which are markers of inflammation,” the researchers wrote. “Fat depots not only act as energy reserve, but they secrete cytokines and other mediators of inflammation, which stimulate production of hs-CRP from the hepatocytes. Cytokines also promote activation and production of white blood cells. Inflammation has been postulated as a major pathogenic pathway for vascular diabetic complications.” – by Jill Rollet

Reference:

Soyoye D, et al. Abstract #253. Presented at: The American Association for Clinical Endocrinologists Annual Scientific & Clinical Congress; May 25-29, 2016; Orlando, Fla.

Disclosure: Endocrine Today was unable to confirm any relevant financial disclosures.