This article is more than 5 years old. Information may no longer be current.
VIDEO: Branched chain amino acid metabolites may be implicated in cardiometabolic disease states
ORLANDO, Fla. — In this video exclusive, Christopher B. Newgard, PhD, director of the Sarah W. Stedman Nutrition and Metabolism Center, professor of pharmacology and cancer biology, and professor of internal medicine at Duke University School of Medicine, discusses his presentation on metabolimics for clinicians.
Through past research, Newgard and his colleagues discovered that a unique metabolic signature exists in patients with obesity between the insulin resistant state and branched chain amino acids and the downstream metabolites of those amino acids.
“We found that the cluster of metabolites was strongly associated with insulin resistance, more strongly than fatty acids,” he said.
Since then, Newgard and colleagues have been investigating whether there is a cause and effect relationship between the cluster of branched chain amino acid metabolites and cardiometabolic disease states.