This article is more than 5 years old. Information may no longer be current.
Metabolic syndrome risk varies by PCOS phenotype
Click Here to Manage Email Alerts
Women diagnosed with a polycystic ovary syndrome phenotype that includes hyperandrogenism and oligo-ovulation or anovulation are at increased risk for metabolic syndrome vs. women with a normoandrogenic phenotype, according to recent study findings.
Researchers from the department of reproductive medicine and infertility at Etlik Zubeyde Hanim Women’s Health Training and Research Hospital in Ankara, Turkey, analyzed data from 100 women newly diagnosed with PCOS between September 2013 and July 2014. Researchers classified women into four phenotypes according to Rotterdam criteria: phenotype A (hyperandrogenism, oligo/anovulation and polycystic ovaries; n = 27); phenotype B (hyperandrogenism, oligo/anovulation; n = 29); phenotype C (hyperandrogenism and polycystic ovaries; n = 20) and phenotype D (oligo/anovulation and polycystic ovaries; n = 24). Researchers compared the prevalence of metabolic syndrome and metabolic risk profile among the four groups.
Researchers found that metabolic syndrome prevalence was higher in phenotypes A and B (29.6% and 34.5%) vs. other phenotypes (10% and 8.3%; P < .001), defining metabolic syndrome based on National Cholesterol Education Program Adult Treatment Panel III diagnostic criteria.
The number of patients with a homeostatic model assessment as an index of insulin resistance (HOMA-IR) measurement of more than 3.8 was higher in hyperandrogenic PCOS phenotypes (types A, B and C) than phenotype D (P = .019). Using logistic regression analysis, researchers found that visceral adiposity index was the only independent predictor of metabolic syndrome in PCOS among five variables (P = .002). For each 1-unit increase in visceral adiposity index, the risk for having metabolic syndrome increased 1.79-fold, according to researchers. Visceral adiposity index also was higher in phenotype B than other types (P < .01). – by Regina Schaffer
Disclosure: The researchers report no relevant financial disclosures.
Click Here to Manage Email Alerts