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Adiponectin levels may predict incident prediabetes risk
Adiponectin level is a powerful risk marker of incident prediabetes in healthy white and black adults with a parental history of type 2 diabetes, study findings showed.
Samuel Dagogo-Jack, MD, FRCP, an Endocrine Today Editorial Board member from the University of Tennessee Health Science Center, Memphis, and colleagues evaluated data from the Pathobiology of Prediabetes in A Biracial Cohort (POP-ABC) study on 151 white adults and 182 black adults (mean age, 44.2 years) to assess baseline adiponectin levels in relation to incident prediabetes.
Samuel Dagogo-Jack
Baseline adiponectin levels ranged from 3.14 µg/mL to 45.8 µg/mL; median value was 7.96 µg/mL and mean value was 9.41 µg/mL. Adiponectin values were higher in women compared with men (10.3 µg/mL vs. 7.27 µg/mL; P < .0001) and in white participants compared with black participants (10.7 µg/mL vs. 8.34 µg/mL; P < .0001).
During a mean follow-up of 2.6 years, 33% of participants developed prediabetes (n = 100) or diabetes (n = 10). Lower mean plasma adiponectin level at baseline was found among participants who progressed to prediabetes/diabetes compared with those who did not (8.37 µg/mL vs. 9.92 µg/mL; P = .012).
An inverse relationship was found between progression to prediabetes/diabetes (OR = 0.48; 95% CI, 0.27-0.86); a 1-standard deviation higher baseline adiponectin level was linked to a 40% lower rate of progression to prediabetes.
“Among healthy African Americans and European Americans with parental history of [type 2 diabetes] enrolled in the POP-ABC study, baseline adiponectin levels were inversely related to the risk of incident prediabetes,” the researchers wrote. “This predictive relationship was evident, despite gender and ethnic differences in baseline adiponectin levels. Based on our finding, it can be predicted that interventions that boost adiponectin levels may offer protection against the risk of dysglycemia, regardless of gender or ethnicity.” – by Amber Cox
Disclosure: The researchers report no relevant financial disclosures.