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Plasma uric acid levels low in adolescents with type 1 diabetes
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Compared with healthy controls, adolescents with type 1 diabetes have significantly lower plasma uric acid levels, according to study findings published in Diabetes Care.
Researchers said an inverse relationship was found between plasma uric acid levels and estimated glomerular filtration rate in type 1 diabetes.
David Cherney, MD, PhD, FRCPC, from the division of nephrology, department of medicine, University Health Network at the University of Toronto, and colleagues evaluated data from the Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial on 188 adolescents with type 1 diabetes and 65 healthy controls to determine the link between plasma uric acid and eGFR, urinary albumin-to-creatinine ratio, blood pressure, endothelial function and arterial stiffness.
Lower eGFR was linked to higher plasma uric acid in controls (P = .0007) and type 1 diabetes (P < .0001). Compared with patients with hyperfiltration and type 1 diabetes, patients with type 1 diabetes and normofiltration had higher plasma uric acid levels (P < .0001); this remained significant after correction for systolic BP z score, sex, HbA1c, BMI z score, age, type 1 diabetes duration, and blood HDL cholesterol (P < .0001). The link between plasma uric acid and eGFR was not significant in controls after controlling for systolic BP z score, sex, HbA1c, BMI z score, age and blood HDL cholesterol.
Lower albumin-to-creatinine ratio was linked to higher plasma uric acid levels in type 1 diabetes (P = .005), whereas this link was not found among controls.
“Even within the physiological range, [plasma uric acid] levels were significantly lower in [type 1 diabetes] adolescent patients compared with [healthy control] subjects,” the researchers wrote. “There was an inverse relationship between [plasma uric acid] and eGFR in [type 1 diabetes], and no associations were observed with [BP], arterial stiffness or endothelial function. Thus, in contrast with adults, in adolescents with [type 1 diabetes], [plasma uric acid] may not yet be associated with cardiorenal abnormalities, highlighting the need to determine whether the effect of [plasma uric acid] on renal risk is modified over time.” – by Amber Cox
Disclosure: One of the researchers received support from the Canadian Institutes of Health Research–Amgen Canada Chair in Kidney Research.
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