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High normal range atrial natriuretic peptide may reduce insulin resistance risk in middle age
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Exposure during middle age to atrial natriuretic peptide within the high normal range appears to be associated with a reduced risk for insulin resistance after 16.5 years of follow-up.
Amra Jujić, PhD, of the department of cardiology at Skane University Hospital in Sweden, and colleagues evaluated data from the Malmö Diet and Cancer Study cardiovascular cohort on 2,243 patients without diabetes. An immunoluminometric sandwich assay was used to measure midregional pro-atrial natriuretic peptide (MR-proANP). At 16.5 years of follow-up, an oral glucose tolerance test was used to measure glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide-1, insulin, glucose and glucagon.
Amra Jujić
Results from linear regression analysis found that for each 1-standard deviation accretion in baseline MR-proANP levels, there was an inverse association with insulin resistance expressed as homeostasis model assessment for insulin resistance (HOMA-IR; P = .001). Results of logistic regression analysis found that for each 1-standard deviation increase of baseline ANP levels, there was a decreased risk of being in the upper quartile of HOMA-IR at follow-up (OR = 0.88; 95% CI, 0.78-0.99). Linear regression analysis revealed that each 1-standard deviation increase of MR-proANP at baseline was linked to greater GIP release (P = .02) 120 minutes after intake of 75 g glucose but not GLP-1 release. No significant differences in these associations were seen after further adjustment for full antihypertensive treatment. No significant correlations were seen for fasting plasma glucose or plasma glucose levels 120 minutes after 75-g glucose intake.
“Midlife exposure to ANP within the high normal range is associated with lower risk of insulin resistance after 16.5 years of follow-up,” the researchers wrote. “Further, midlife exposure to ANP within the high normal range is associated with greater postchallenge GIP secretion at follow-up, possibly explaining the lower prevalence of insulin resistance.” – by Jennifer Byrne
Disclosure: The researchers report no relevant financial disclosures.
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