This article is more than 5 years old. Information may no longer be current.
Urinary pH linked to renovascular disorder in diabetes
Click Here to Manage Email Alerts
Urinary pH may be useful in predicting the onset of renovascular disorder in patients with diabetes, according to recent findings.
In the 10-year, prospective, observational cohort study, Susumu Ogawa, MD, PhD, of Tohoku University in Japan, and colleagues evaluated 350 patients with diabetes to determine the relationship between urinary pH and renovascular damage. Participants were enrolled in the study between January and March 2003.
At baseline and in 2013, researchers collected data on age, sex, BMI, blood pressure, heart rate, serum lipid levels, electrolytes, urinary pH, plasma glucose concentration, 8-hydroxy-20 deoxyguanosine (8-OHdG), HbA1c, urinary albumin-creatinine ratio, uric acid levels, estimated glomerular filtration rate (eGFR), blood urea nitrogen, alanine aminotransferase (ALT), aspartate transaminase, chloride, hemoglobin, waist circumference, pulse wave velocity (PWV), ankle brachial index and intima-media thickness (IMT).
Compared with baseline measurements, reductions were found at the study endpoint for HbA1c, BP, and eGFR. Increases were found for urinary albumin-creatinine ratio, uric acid levels and IMT.
An inverse association was found between urinary pH and 8-OHdG, BMI, uric acid, urinary albumin-creatinine ratio, percent change in IMT, percent change in PWV and change in log abumin-creatinine ratio. A positive association was found between urinary pH and the percent change in eGFR.
“Decreased [urinary pH], in particular, was a powerful predictive factor for renovascular disorders,” the researchers wrote. “[Urinary pH] is always determined as part of routine testing; it is a noninvasive and inexpensive test. The finding that [urinary pH] can predict long-term renovascular disorders has significant clinical value. – by Jennifer Byrne
Disclosure: The researchers report no relevant financial disclosures.
Click Here to Manage Email Alerts