This article is more than 5 years old. Information may no longer be current.
Lower BMD results in higher risk for prevalent vertebral fractures
Click Here to Manage Email Alerts
A higher risk for prevalent vertebral fractures associated with lower bone mineral density was found in men with and without type 2 diabetes, according to recent study findings presented at The American Society for Bone and Mineral Research Annual Meeting.
“Type 2 diabetes is associated with a 50% to 80% increased risk of hip fractures as well as 30% to 70% increased risk of fracture of the humerus and foot,” the researchers wrote. “However, to date, very limited information is available on the vertebral fracture risk in [men with diabetes]. Moreover, although BMD is strongly associated with vertebral fractures in the general population, previous results have shown no association between BMD and vertebral fractures in [type 2 diabetes].”
Nicola Napoli, MD, of the University Campus Bio-Medico di Roma, Italy, and colleagues evaluated data from the Osteoporotic Fractures in Men (MrOS) study on 5,994 men aged older than 65 years with and without type 2 diabetes to determine the prevalence and incidence of vertebral fractures as well as if lumbar spine BMD is associated with vertebral fractures.
Nicola Napoli
Higher spine areal BMD and higher integral and trabecular volumetric BMD was found among those with type 2 diabetes compared to those without (P < .001 for all).
No significant differences were found between the groups for vertebral fracture prevalence or risk for incident vertebral fracture following adjustment for age, clinic site, race, BMI, areal BMD and volumetric BMD.
A negative association was found between spine areal BMD and prevalent vertebral fractures in the type 2 diabetes group (OR = 0.69; 95% CI, 0.52-0.91) and the group without type 2 diabetes (OR = 0.56; 95% CI, 0.49-0.63); similar results were found for volumetric BMD.
“In conclusion, [type 2 diabetes] is not associated with increased risk of prevalent or incident [vertebral fractures] in elderly men,” the researchers wrote. “Lower BMD is associated with higher risk of prevalent [vertebral fractures] in diabetes as well as [men without diabetes].” – by Amber Cox
Reference:
Napoli N, et al. Abstract 1067. Presented at: The American Society for Bone and Mineral Research Annual Meeting; Oct. 9-12, 2015; Seattle.
Disclosure: Napoli reports no relevant financial disclosures.