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Anti-Müllerian hormone levels not associated with fertility
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In fertile women with a history of one or two pregnancy losses, lower and higher anti-Müllerian hormone levels were not associated with fecundability in unassisted conceptions, according to recent study findings published in The Journal of Clinical Endocrinology & Metabolism.
According to the researchers, the findings are not supportive of routine anti-Müllerian hormone (AMH) testing for preconception counseling in young, fertile women.
Enrique F. Schisterman , PhD, of the Eunice Kennedy Shriver National Institute of Child Health and Human Development, and colleagues evaluated data from the Effects of Aspirin in Gestation and Reproduction (EAGeR) trial on 1,202 women aged 18 to 40 years with a history of one or two pregnancy losses who were actively attempting pregnancy to determine the effect of AMH on fecundability in women with proven fecundity.
Enrique F. Schisterman
Preconception AMH levels were defined as low (< 1 ng/mL; n = 124), normal (referent; 1 to 3.5 ng/mL; n = 595) and high (> 3.5 ng/mL; n = 483).
Sixty-six percent of participants with low AMH achieved a human chorionic gonadotropin (hCG)-detected pregnancy compared with 65.2% of those with normal AMH and 65.2% of those with high AMH.
Compared with normal AMH, low AMH (fecundability OR = 1.13; 95% CI, 0.85-1.49) and high AMH (fecundability OR = 1.04; 95% CI, 0.87-1.24) were not associated with fecundability.
No significant association was found between low or high AMH and achieving either hCG-detected or clinically confirmed pregnancy after restricting the analysis to number of prior live births, number of previous pregnancy losses and time since most recent loss.
“Thus, AMH likely does not have utility for preconception counseling purposes in fecund women, though further studies may elucidate some utility for AMH among women without proven fecundity (eg, nulligravid women), or among women with either no or recurrent pregnancy loss,” the researchers wrote. – by Amber Cox
Disclosure: The researchers report no relevant financial disclosures.
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