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Serum selenoprotein P inversely linked to kidney function in CKD
In patients undergoing chronic hemodialysis for kidney disease, serum levels of selenoprotein P appear to be significantly decreased, while thyroid hormone profile remains unaltered, according to recent findings.
In the study, Walter Reinhardt, MD, of the department of nephrology at the University Hospital Essen in Germany, and colleagues prospectively evaluated 180 patients who presented to the outpatient nephrology department of the University Hospital Essen for additional assessment of presumed kidney disease. Participants included patients in stages 1 through 5 of chronic kidney disease. Additionally, they evaluated 70 patients on chronic hemodialysis treatment three times a week for a mean duration of 3.4 years.
The researchers measured serum concentrations of thyrotropin, thyroxine (T4), free thyroxine (fT4), triiodothyronine (T3), free triiodothyronine (fT3), thyroxine-binding globulin (TBG), C-reactive protein and serum selenoprotein P (SePP). Patients were also assessed for renal function.
Researchers found that SePP concentrations increased in more advanced cases of CKD (P = .029). Conversely, patients on hemodialysis had significantly lower SePP levels vs. the CKD patients (P < .001). While CKD patients had an inverse association between serum SePP levels and T4 (P = .039) and fT4 (P = .039) concentrations, no association was found between SePP concentrations and T3, fT3, reverse T3, T3/T4, reverse T3/T3, reverse T3/T4 or TBG levels. An inverse relationship was found between SePP and C-reactive protein (P = .029). No association was found between SePP and any evaluated measures of thyroid hormone in the patients undergoing chronic hemodialysis treatment.
“SePP concentrations were found within the reference range in the presence of decreasing T4 and fT4 concentrations,” the researchers wrote. “[Thyroid hormone} degradation to [reverse] T3 seems to be unaffected by SePP status in patients with CKD. Significantly lower SePP values were observed in patients undergoing [chronic hemodialysis], but this is not associated with serum [thyroid hormone] parameters.”
Disclosure: The researchers report no relevant disclosures.