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Increased DPP-IV activity predicts osteoporosis in postmenopausal women
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Increased plasma DPP-IV activity is independently associated with osteoporosis in postmenopausal women with normal glucose tolerance, according to research in The Journal of Clinical Endocrinology & Metabolism.
In a cross-sectional study of postmenopausal women in China, researchers found that DPP-IV activity was positively associated with the bone turnover markers C-terminal telopeptide of type 1 collagen (CTX) and osteocalcin, suggesting that high DPP-IV activity was associated with a high bone turnover rate.
Tianpeng Zheng, MD, of the department of endocrinology and metabolism at Guilin Medical University in Guangxi province, China, and colleagues analyzed data from 744 postmenopausal women from China aged 47 to 76 years (mean age, 60 years) with normal glucose tolerance. Researchers collected blood samples after an overnight fast to measure DPP-IV activity, as well as serum calcium, serum phosphorus, serum 25-hydroxyvitamin D, fasting plasma glucose, active glucagon-like peptide-1, fasting insulin, lipid profiles and bone turnover markers. Researchers used DXA to measure areal bone mineral density at the lumbar spine and femoral neck.
Researchers found that the risk for osteoporosis increased with higher levels of DPP-IV activity, with osteoporosis risk significantly higher for participants in the highest DPP-IV quartile when compared with the lowest quartile (OR = 3.01; 95% CI, 1.66-5.43). Participants in the highest quartile of DPP-IV activity had higher levels of triglycerides, total cholesterol, insulin resistance, interleukin-6, high-sensitivity C-reactive protein, CTX and osteocalcin, and lower levels of BMD and active GLP-1 when compared with participants in the lowest quartile (P < .05). Researchers found a positive association between DPP-IV activity and triglycerides, total cholesterol, insulin resistance, IL-6, CTX and osteocalcin, and a negative association between DPP-IV activity and active GLP-1 and BMD (P < .05).
“From a clinical perspective, we speculate that the underlying mechanisms may be partly explained by DPP-IV’s effect on inflammation and insulin resistance, not altered lipid profiles or active fasting GLP-1,” the researchers wrote. “Moreover, independent of the mechanism, elevated DPP-IV activity in postmenopausal women could be a marker or warning signal predicting the development of osteoporosis.”
Researchers said additional studies with different endpoints, including fracture rates and bone quality analysis, are needed to help identify postmenopausal women most at risk for osteoporosis. – by Regina Schaffer
Disclosure: The researchers report no relevant financial disclosures.
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