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No seasonal variation in 25-(OH)D levels found for primary hyperparathyroidism
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Primary hyperparathyroidism disease severity and seasonal variation in serum 25-hydroxyvitamin D levels were not apparent in the northeastern United States, according to recent study findings published in The Journal of Endocrinology & Metabolism.
“Demonstration of seasonal variability in 25-(OH)D levels and disease severity in [primary hyperparathyroidism] could support season-specific vitamin D targets or greater vitamin D supplementation in the winter in [primary hyperparathyroidism] in this population already at risk for skeletal loss and fracture,” the researchers wrote.
Marcella D. Walker, MD, MS, of Columbia University, and colleagues evaluated 100 patients with primary hyperparathyroidism to determine whether seasonal variability exists for 25-(OH)D levels with the increasing trend of vitamin D supplementation.
Marcella D. Walker
The mean serum calcium level was 10.8 ± 1 mg/dL, the mean 25-(OH)D levels was 29 ± 10 mg/mL and mean vitamin D intake was 1,493 ± 1,574 IU daily. Nineteen percent of participants had vitamin D deficiency (< 20 ng/mL), whereas 54% were deficient or insufficient (< 30 ng/mL). Sixty-five percent of participants took a median dose of 1,643 ± 1,496 IU of vitamin D.
Participants taking vitamin D supplementation had higher 25-(OH)D levels (P < .05), lower prevalence of 25-(OH)D less than 20 ng/mL (P < .0001) and 25-(OH)D less than 30 ng/mL (P = .0001) compared with those not taking vitamin D supplementation. Mean sun exposure did not significantly differ between the group taking and not taking vitamin D supplementation.
By season, levels of 25-(OH)D, parathyroid hormone, 1,25-(OH)D, calcium or prevalence of 25-(OH)D less than 20 ng/mL and less than 30 ng/mL did not differ among participants. Among participants not on vitamin supplementation, seasonal differences also were not found for levels of 25-(OH)D, parathyroid hormone, 1,25-(OH)D, calcium or prevalence of 25-(OH)D less than 20 ng/mL and less than 30 ng/mL.
“The seasonal variability in 25-(OH)D levels or in markers of [primary hyperparathyroidism] disease severity that we documented 20 years ago in a cohort with [primary hyperparathyroidism] from the same geographic location no longer exists,” the researchers wrote. “The findings suggest that [primary hyperparathyroidism] disease severity is not exacerbated in the winter months in populations with high levels of vitamin D supplementation. This study represents the first assessment of seasonal 25-(OH)D variation in a [primary hyperparathyroidism] cohort with high vitamin D intake.” – by Amber Cox
Disclosure: The researchers report no relevant financial disclosures.
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