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High BP raises risk for incident diabetes among Koreans
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Prehypertension and hypertension appear to be associated with subsequent onset of diabetes among Koreans in the long term, according to recent findings.
In the 10-year, prospective, community-based study, Soo Lim, MD, MPH, PhD, of the Seoul National University College of Medicine, and colleagues evaluated data from 8,359 adults (3,930 men) without diabetes enrolled in the Korean Genome and Epidemiology Study. The researchers classified the blood pressure of these patients as normal (n = 4,809; BP, < 120/80 mm Hg), prehypertension (n = 2,141; BP, 120-139/80-89 mm Hg), stage 1 hypertension (n = 804; BP, 140-159/90-99 mm Hg) and stage 2 hypertension (n = 605; BP, 160/100 mm Hg). The researchers used WHO criteria to define incident diabetes as glucose concentrations above of 125 mg/dL or postload glucose levels 200 mg/dL or more after the 75-g oral glucose tolerance test (OGTT).
Over the course of a 10-year follow-up, incident diabetes occurred in 1,195 participants (14.3%) overall. The diabetes incidence by BP categories was as follows: normal BP group, 11.1%; prehypertension group, 17%; stage 1 hypertension group, 17.7%; and stage 2 hypertension group, 25.8% (P < .001).
The hazard risks for diabetes after adjusting for anthropometric factors, family history of diabetes, biochemical measures (including C-reactive protein, fasting glucose and postload 2-hour glucose) and the use of cholesterol lowering medication were as follows: 1.23 (95% CI, 1.06-1.42 in the prehypertension group, 1.26 (95% CI, 1.04-1.54) in the stage 1 hypertension group and 1.6 (95% CI, 1.3-1.96) in the stage 2 hypertension group.
According to the researchers, this is among the largest community-based longitudinal cohort studies to identify an association between hypertension risk and subsequent diabetes onset in Korean individuals.
“Our findings support a strong and graded association between high BP and incident diabetes in a Korean population, and further emphasize that a common link between these two disorders appears to be prevalent across many ethnic groups,” the researchers wrote. – by Jennifer Byrne
Disclosure: The researchers report no relevant financial disclosures.
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