This article is more than 5 years old. Information may no longer be current.
Metabolic control of children with type 1 diabetes improved during 12-year period
Click Here to Manage Email Alerts
Analysis of data from a national childhood-onset diabetes register showed that a significant and clinically meaningful decrease of HbA1c level in pediatric patients with type 1 diabetes was associated with treatment modality during a 12-year period, according to research published in Diabetes Technology & Therapeutics.
“The metabolic control of the entire nationwide pediatric type 1 diabetes population significantly improved during the 12-year observational period with a low rate of severe acute complications events. The improvement was associated with the treatment modality. Additional efforts and solutions are necessary to further improve metabolic control and the quality of life of young people with type 1 diabetes,” Klemen Dovc, MD, of the department of pediatric endocrinology, diabetes and metabolism at the University Medical Center-University Children’s Hospital in Ljubljana, Slovenia, and colleagues wrote.
Researchers in Slovenia examined data from the Slovene childhood-onset type 1 diabetes register, a prospective childhood-onset diabetes register of 866 pediatric patients who had an initial diagnosis of type 1 diabetes at age 0 to younger than 18 years. All patients had at least 1 year of follow-up until aged 22.99 years. Outpatient visits and measurements were recorded for the patients about every 3 months.
Researchers used multivariable linear and logistic regression models to analyze the temporal trends of metabolic control in these patients during a 12-year observational period from 2000 to 2011.
During the 12-year observation period, HbA1c significantly decreased in the national cohort (P<.001). The HbA1c decrease was found to be significantly associated with age, treatment modality and duration of diabetes. Also, in the population that used insulin pumps (74%), the incidence rate of severe acute complications was low, according to Dovc and colleagues.
“The present study demonstrated a clear shift to younger age at onset of type 1 diabetes with a median decrease from 12.68 to 7.53 years. A similar decrease was previously shown in other studies, also including our region,” the researchers wrote.
Disclosure: The researchers report no relevant financial disclosures.
Click Here to Manage Email Alerts