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Lipid profile improvements found with irisin depletion
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Improvements in lipid profiles may be associated with the depletion of the recently discovered myokine, irisin, among patients with metabolic syndrome following the nutritional intervention of a hypocaloric diet, according to research published in Clinical Endocrinology.
The study findings are a subanalysis of a larger nutritional intervention study, the RESMENA-S project.
Rocio de la Iglesia, PhD, of the department of nutrition, food science and physiology at the University of Navarra in Pamplona, Spain, and colleagues analyzed anthropometric measurements, biochemical markers and plasma irisin levels in 93 study participants. Data were recorded before and after the participants followed an 8-week energy-restricted weight-loss program. All participants were white adults; 52 were men and 41 were women. All were diagnosed with metabolic syndrome. For the final analysis, 84 participants completed the program and were included in the study results.
At the end of the 8-week diet program, researchers recorded weight loss (–6.9%), along with significantly reduced global plasma irisin levels (–72 ± 100.9 ng/mL, P<.001).
Changes in some atherogenic-related variables such as total cholesterol, total/HDL ratio, LDL and apolipoprotein B significantly correlated with the depletion of irisin. The association was independent of changes in body weight.
“In the present study, it was found that the variation in atherogenic parameters paralleled the changes in irisin levels after weight-loss therapy. Therefore, these results suggest that irisin could also be involved in fat metabolism homeostasis or lipid disorders,” the researchers wrote.
Disclosure: The researchers report no relevant financial disclosures. This study was supported by the Dutch Arthritis Association (Reumafonds), a nonprofit fundraising organization.
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