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Increased left atrial volume index predicted CV mortality in type 2 diabetes
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Increased left atrial volume index was an independent and additional predictor of cardiovascular morbidity and mortality among patients with type 2 diabetes, with no history of cardiovascular disease, according to data published in the Journal of the American College of Cardiology.
Due to the persistence of the prognostic value of left atrial volume index (LAVi), Mikael K. Poulsen, MD, PhD, of the department of cardiology at Odense University Hospital in Denmark, and colleagues wrote that it could be a simple but important tool in risk stratification of patients with type 2 diabetes.
The researchers examined 305 patients with type 2 diabetes, without a known CVD. They were divided according to LAVi ≥32 ml/m2; the median follow-up for the occurrence of major cardiac events and death was 5.6 years, according to data.
Researchers reported LAVi ≥32 mL/m2 in 105 patients (34%). During follow-up, 60 patients (20%) demonstrated the composite endpoint. Of those, 28 (9%) died, researchers wrote.
Additionally, those with LAVi ≥32 mL/m2 displayed a significantly greater cardiac event rate (P<.001) and death rate (P=.002).
Only LAVi ≥32 mL/m2 was a predictor of the composite endpoint (HR=1.82; 95% CI, 1.08-3.07) after adjustments for age and hypertension.
“Although the present study does not offer insight into the mechanism causing [left atrial] pressure overload, it seems plausible that there exists a link between type 2 diabetes and diastolic dysfunction rather than assuming that this is a coincidental association,” researchers wrote.
Disclosure: This study was funded by the Danish Cardiovascular Research Academy, the Danish Diabetes Association, and the Danish Heart Foundation. Beck-Nielsen received a research grant from Novo Nordisk. All others report no relevant financial disclosures.
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