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eGFR corrected by HbA1c better measure of serum creatinine
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Estimated glomerular filtration rate may overestimate levels of serum creatinine as glycemic control worsens, according to Akihiro Tsuda, MD, of Osaka City University Graduate School of Medicine in Japan, and colleagues.
In their recent study, Tsuda and colleagues reported that eGFR corrected by HbA1c could be a clinically meaningful strategy.
Patients (n=80) included those with diabetes (n=40) and those without diabetes (n=40), aged 56.6 years (43.8% men).
Although insulin clearance was not significantly different between the patient groups (P=.2866), each eGFR measurement from the patients with diabetes was significantly higher compared with those without diabetes (P<.01), according to data.
In addition, serum creatinine levels in patients with diabetes were significantly lower compared with patients without diabetes (P<.0001).
“These results indicate that, in order to accurately evaluate renal function, eGFR should be corrected by the glycemic control indices in patients with diabetes, particularly in those with poorer glycemic control,” researchers wrote. “Since serum creatinine and HbA1c are among the laboratory data that we generally measure in clinical practice, compared with serum cystatin C and glycated albumin, we consider that eGFR [based on serum creatinine] corrected by HbA1c is the most feasible and useful in the evaluation of renal function.”
Therefore, the researchers suggest larger studies to determine the clinical validity of eGFR correction by HbA1c.
Disclosure: The researchers report no relevant financial disclosures.
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