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High vitamin D levels linked to low circulating TSH in younger Thai population
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Vitamin D status was associated with thyroid-stimulating hormone levels in a population-based cohort in Thailand, according to researchers. Specifically, high vitamin D status in younger people was associated with low circulating TSH.
Using the Thailand 4th National Health Examination Survey, researchers randomly selected 2,582 adults aged 15 to 98 years according to geographical region. Serum 25-hydroxyvitamin D, TSH, thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TgAb) levels were measured in all participants.
Positive serum TgAb was associated with higher TSH levels and lower total serum 25(OH)D levels. Additionally, in TgAb-positive adults, vitamin D insufficiency was more prevalent compared with those participants who were TPOAb- and TgAb-negative, whether based on cutoff values of 20 ng/mL or 40 ng/mL (8.3% vs. 5.6% or 47.6% vs. 42.0%; P<.05).
After controlling for age and sex, however, vitamin D status was not associated with positive TPOAb and/or TgAb, according to the researchers.
“To explore the probable interaction between vitamin D status and age on serum TSH, analyses were performed according to age tertiles; it was found that higher 25(OH)D levels were independently associated with lower TSH, but only in subjects in the lowest age tertile,” they wrote.
Reference:
- Chailurkit L. Thyroid. 2012;doi:10.1089/thy.2012.0001.