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DPP-based lifestyle interventions reduced BMI more than usual care
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Researchers at the Palo Alto Medical Foundation Research Institute in California evaluated two adapted Diabetes Prevention Program lifestyle interventions in overweight or obese adults. According to data, they found that the programs improved body weight as measured by BMI, waist circumference and fasting plasma glucose levels vs. patients treated with usual care for 15 months.
The patients (mean age, 52.9 years) were randomly assigned to a coach-led group intervention (n=79), a self-directed DVD intervention (n=81) or a usual care group (n=81). Based on patient data, 54% had pre-diabetes, 87% had metabolic syndrome and 41% had both conditions.
According to baseline data, mean BMI was 32 among patients. The mean change in BMI from baseline was –2.2 at 15 months in the coach-led group vs. –0.9 in the usual care group (P<.001), researchers wrote.
Thirty-seven percent of those in the coach-led group and 35.9% of those in the self-directed groups reached the 7% Diabetes Prevention Program (DPP)-based weight-loss goal. Only 14.4% met the weight-loss goal in the usual care group, they wrote.
FPG levels demonstrated a mean change of 0.2 mg/dL in the usual care group compared with –4.2 mg/dL in the coach-led group (P<.001), according to data. Similarly, waist circumference measurements had a mean change of –2.2 cm in the usual care group compared with –5.8 cm in the coach-led group (P<.001).
There were five serious adverse events in four patients in the coach-led group, possibly linked to the intervention. One patient in the coach-led group developed type 2 diabetes during the 15-month study.
These findings may encourage further alternative lifestyle interventions, the researchers wrote.
Disclosure: One of the researchers has provided consulting services to Mylan Pharmaceuticals.
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