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High BMI, BP likely increases risk for death from prostate cancer
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Researchers in Sweden found that high BMI and elevated blood pressure levels were linked to an increased risk for death from prostate cancer, according to study results published in Cancer.
Christel Häggström, MSc, of the department of surgical and perioperative sciences, urology and andrology at the Umeå University Hospital in Sweden, and colleagues conducted a prospective study within the Metabolic Syndrome and Cancer (Me-Can) project, an ongoing study in Norway, Sweden and Austria.
“We found that high BMI and elevated blood pressure were associated with an increased risk of death from prostate cancer. When taking all factors into account in the model, blood pressure was found to have the strongest association with risk,” the researchers wrote.
Of the 289,866 men included, 127,846 (44%) were overweight (BMI of 25-30); 30,853 (11%) were obese (BMI ≥30); 110,369 (38%) had hypertension; and 113,496 (39%) were nonsmokers at the time of enrollment. The mean age of the patients was 44 years.
According to data, 6,673 men were diagnosed with prostate cancer and 961 died during a mean follow-up of 12 years. The researchers wrote that men who tested for high levels of glucose (RR=0.82; 95% CI, 0.62-1.08) and triglycerides (RR=0.88; 95% CI, 0.74-1.04) had a decreased risk for prostate cancer.
The researchers wrote that the prostate cancer incidence rate in the cohort of 6,673 men was 202 per 100,000 person-years, and the mortality rate was 33 per 100,000 person-years.
Additionally, those with high BMI (RR=1.36; 95% CI, 1.08-1.71), elevated systolic BP (RR=1.62; 95% CI, 1.07-2.45) and high composite z score (RR=1.13; 95% CI, 1.03-1.25) were linked to an increased risk for death due to prostate cancer.
The researchers suggest that the findings add to a broader public health issue, in which motivation should be made to control metabolic factors to reduce the risk for cardiovascular disease, diabetes and prostate cancer death.
Disclosure: The researchers report no relevant financial disclosures.
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