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Prognostic signs identified for ovarian tissue freezing in girls with Turner syndrome
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Signs of spontaneous puberty, mosaicism and normal hormone concentrations were among the most positive prognostic factors for finding follicles for ovarian tissue freezing in girls with Turner syndrome.
Researchers from Sweden analyzed clinical and lab parameters as well as ovarian follicle counts for girls with Turner syndrome aged 8 to 19.8 years (n=57). The study objective was to evaluate which girls might benefit from ovarian tissue freezing for fertility preservation.
The researchers biopsied ovarian tissue in 47 girls and found follicles in the tissue piece analyzed histologically in 26% of the girls.
Follicles were found in six of seven girls with mosaicism, six of 22 girls with structural chromosomal abnormalities, three of 28 girls with karyotype 45X, eight of 13 girls with spontaneous menarche and 11 of 19 girls with signs of spontaneous puberty.
The group aged 12 to 16 years had the highest proportion of girls with follicles, and normal follicle-stimulating hormone and anti-Müllerian hormone concentrations for age and pubertal stage were more frequent in those with follicles.
“The experience from this study convinced us that the possibility to perform ovarian biopsy in young girls with Turner’s syndrome is an important step in possibly overcoming infertility in this group of girls,” the researchers wrote.
J Clin Endocrinol Metab. 2009;94:74-80.