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Obesity not an independent risk factor for contrast nephropathy
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Renal Week 2009
Obesity was not an independent risk factor for contrast nephropathy in hospitalized U.S. veteran patients, according to data presented at Renal Week 2009.
Previous studies have linked obesity and inflammation, and researchers conducted a study to examine whether obesity is independently associated with acute kidney injury contrast nephropathy. Researchers reviewed chart records of 803 hospitalized U.S. veterans with acute kidney injury (n=129; 124 men; 107 white) and contrast nephropathy (n=101; 96 men; 84 white) who were given radiocontrast. Acute kidney injury was defined as an absolute rise in serum creatinine of >0.3mg/dL, and contrast nephropathy was defined as an absolute rise of 0.5mg/dL, within 72 hours of contrast dosing.
Overall, 16.1% of patients had acute kidney injury and 12.6% had contrast nephropathy.
When stratified by BMI, obesity was not associated with development of acute kidney injury (P=.37) or contrast nephropathy (P=.54) after radiocontrast exposure.
Patient demographics were similar; however, those with acute kidney injury or contrast nephropathy were more likely to be older and have diabetes.
“These findings are consistent with the known prevalence of contrast nephropathy and associations of age and diabetes with contrast nephropathy, but would suggest that obesity is not an independent risk factor for contrast nephropathy,” the researchers concluded.
Association Between Obesity and Contrast Nephropathy or Acute Kidney Injury |
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Manalo R. #TH-PO044. Presented at: Renal Week 2009; Oct. 27- Nov.1, 2009; San Diego.