This article is more than 5 years old. Information may no longer be current.
Metabolic syndrome predicted CKD risk
Cheng HT. J Clin Endocrin Metab. 2012;doi:10.1210/jc.2011-2658.
Click Here to Manage Email Alerts
Metabolic syndrome was linked to an increase in risk for chronic kidney disease of nearly 80% in participants without diabetes, according to study results.
Researchers from a tertiary hospital in Taiwan aimed to increase their understanding of the effect of metabolic syndrome and insulin resistance on the development of new CKD and the decline in renal function. The prospective cohort study involved 1,456 Asians aged at least 65 years. Participants were followed for an average of 3.15 years.
The final analysis involved 652 nondiabetic participants who were measured for insulin resistance using the homeostasis model assessment formula. The primary outcome measures included the prevalence and incidence of CKD and the annual decline of the estimated glomerular filtration rate.
The adjusted OR for prevalent CKD in association with metabolic syndrome was 1.778 (95% CI, 1.188-2.465). Other results indicated that the HR for rapid decline in renal function was 1.042 (95% CI, 0.802-1.355). Incident CKD was linked to an HR of 1.931 (95% CI, 1.175-3.174).
With each one-unit increment of insulin resistance, the OR for prevalent CKD was raised 1.312-fold (95% CI, 1.114-1.545). The same incremental increase in insulin resistance was linked to a 1.278-fold (95% CI, 1.098-1.488) increase in the OR for proteinuria.
No link was observed between insulin resistance and incident CKD. A 1.16-fold (95% CI, 1.06-1.26) elevation in the HRs of the decline in renal function occurred with the increment of insulin resistance per unit.
“Metabolic syndrome predicts the risks of prevalent and incident CKD, whereas insulin resistance is associated with prevalent CKD and rapid decline in renal function in elderly individuals,” the researchers concluded.
 |
Follow EndocrineToday.com on Twitter. |