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Hyperthyroidism linked to risk for venous thrombosis

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Patients with recent hyperthyroidism may have a more than 10-fold increased risk for venous thrombosis.

“The aim of our study was to assess the effect of hyperthyroidism on the occurrence of clinical venous thrombosis,” J. Debeij, MD, of the department of clinical epidemiology at Leiden University Medical Center, in the Netherlands, said at the Endocrine Society’s 90th Annual Meeting.

Using questionnaires and medical records, the researchers conducted a population-based control study that included 4,494 patients with venous thrombosis and 5,896 controls. Deep-venous thrombosis was reported in 57% of patients and pulmonary embolism in 30%, according to the abstract.

“We found that patients with hyperthyroidism had, within 10 years of diagnosis, a 2.4-fold increased risk of venous thrombosis,” he said.

Hyperthyroidism was diagnosed in 16 cases and eight controls within 10 years of their thrombotic event, resulting in this increased risk. Debeij reported that 11 patients and one control had a diagnosis of hyperthyroidism within one year of their thrombotic event, resulting in a relative risk of 13.2 (95% CI, 1.7-102.3).

“Recent hyperthyroidism increases the risk for venous thrombosis more than 10-fold, and hyperthyroidism is a rare but strong risk factor for venous thrombosis,” he said.

For more information:

• Debeij J, Dekkers OM, Doggen CJM et al. OR42-3. Recent hyperthyroidism is associated with an increased risk for venous thrombosis. Presented at: the Endocrine Society’s 90th Annual Meeting; June 15-18, 2008; San Francisco.