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Bariatric surgery had favorable effect on MI in obese patients with high blood glucose
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The Obesity Society’s 27th Annual Scientific Meeting
Bariatric surgery had no significant effect on myocardial infarction during a study period of 20 years; however, there was a significant effect of surgery on MI among patients with baseline gluose values >4.72 mmol/L, according to data from the Swedish Obese Subjects study.
The SOS study is the first intervention trial to provide prospective, controlled data on MI in an obese cohort. The study included 2,010 obese men and women who underwent bariatric surgery and 2,037 obese matched controls who received a conventional obesity treatment. Median follow-up was 12.8 years.
At baseline, BMI was 41.8 in the surgery group. It decreased –30.3 kg at year one, –28.52 kg at year two, –19.9 kg at year 10 and –20.8 kg at year 15. In the control group, with a baseline BMI of 40.9, body weight decreased –0.9 kg at year one, –0.1 kg at year two, increased 1.3 kg at year 10 and decreased –1.8 kg at year 15 (P<.001).
The researchers reported a significant association between treatment low- or high-glucose interaction and MI (P=.007).
Bariatric surgery was associated with a favorable effect on the incidence of MI in patients with fasting blood glucose ≥4.72 mmol/L at baseline (61 vs. 78 MI cases; HR=.66, 95% CI 0.47-0.92; P=.014). However, surgery was not an advantage for patients with blood glucose <4.72 mmol/L (43 vs. 35 cases; HR=1.40; 95% CI 0.90-2.19; P=.14).
For more information:
- Sjostrom L. Late-breaker presentations. Presented at: the Obesity Society’s 27th Annual Scientific Meeting; Oct. 24-28, 2009; Washington.
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