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Adiponectin linked to diabetes risk, independent of BMI

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High-molecular-weight adiponectin may be linked to diabetes pathogenesis, independent of BMI, according to recently published data.

Researchers from the Harvard School of Public Health and other sites in Massachusetts, and the NIH in Maryland, conducted a prospective, case-controlled study that included 1,038 women with type 2 diabetes and 1,136 matched controls. The researchers measured total and high-molecular-weight adiponectin and resistin plasma levels.

Higher levels of total and high-weight-molecular adiponectin were associated with a lower risk for type 2 diabetes in multivariate analyses that included BMI (OR=0.17 for total adiponectin; OR=0.10 for high-molecular-weight adiponectin).

After adjusting for total adiponectin, a higher ratio of high-molecular-weight to total adiponectin was linked to a lower risk for type 2 diabetes (OR=0.45; 95% CI, 0.31-0.65), according to the researchers.

Higher levels of resistin were associated with a higher risk for diabetes in multivariate analyses without BMI (OR=1.68; 95% CI, 1.25-2.25); however, adjusting for BMI made the association insignificant (OR=1.28; 95% CI, 0.93-1.76).

Ann Intern Med. 2008;149:307-316.