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Surgical menopause not associated with significant increase in fracture risk
Vesco KK. Menopause. 2012;doi:10.1097/gme.0b013e318239caeb.
Postmenopausal women who underwent premenopausal bilateral oophorectomy did not have a substantially increased, long-term risk for nonvertebral fractures vs. postmenopausal women with intact ovaries, even without postmenopausal estrogen therapy, according to researchers, who called these results reassuring.
Using 21 years worth of prospectively collected data on incident fractures from the ongoing Study of Osteoporotic Fractures, researchers assessed the risk for hip, wrist and nonvertebral fractures among 6,616 community-dwelling women without previous bilateral hip fracture. Women were aged at least 65 years at enrollment. Characteristics of women who underwent surgical menopause and those who underwent natural menopause were compared using chi-squared and t tests; the risk for fracture was estimated using multivariable Cox proportional hazards regression models stratified by baseline oral estrogen use.
Mean age at menopause and current oral estrogen use — as well as other baseline characteristics — differed significantly among the two groups (44.3 years vs. 48.9 years; P<.001) and (30.2% vs. 6.5%; P<.001). Women who underwent surgical menopause did not have significantly higher fracture rates, even among those who had never used oral estrogen (hip fracture: HR=0.87; 95% CI, 0.63-1.21; wrist fracture: HR=1.10; 95% CI, 0.78-1.57; any nonvertebral fracture: HR=1.11; 95% CI, 0.93-1.32).
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