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Poor glycemic control, heart failure link strong in patients with type 2 diabetes
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EASD 47th Annual Meeting
LISBON — Data describing the relationship between glycemic control and heart failure in patients with type 2 diabetes remains conflicted. However, in a new study, researchers from Sweden reported that impaired glycemic control is strongly and independently associated with hospitalization for heart failure in this patient population.
Marcus Lind, MD, from the Institute of Medicine at the University of Gothenburg, and NU-Hospital Organization, Uddevalla, Sweden, and colleagues examined data for more than 83,000 patients with type 2 diabetes (mean age, 65.8 years) who were included in the Swedish National Diabetes Register between 1998 and 2003. All patients were free from HF initially and were followed through December 2009.
They found that more than 13% of patients were hospitalized for primary or secondary HF diagnosis during a median follow-up of 7.2 years. Unadjusted incidence rates for HF ranged from 13.8 per 1,000 person-years (95% CI, 12.9-14.8) for those with an HbA1c level ≤6.0% to 25.8 per 1,000 person-years (95% CI, 23.5-28.4) for those with an HbA1c ≥10%.
Relative risk was adjusted for age, sex, diabetes duration, smoking, BMI, systolic and diastolic blood pressure, prior or intervening myocardial infarction, atrial fibrillation, heart valve surgery, ischemic heart disease, microalbuminuria, antihypertensive and antidiabetic medication. The researchers calculated a hazard ratio of 2.01 for patients with updated mean HbA1c ≥10% (95% CI, 1.51-1.93) compared with those with HbA1c ≤6%. For each percentage unit increase in HbA1c, the HR was 1.16 (95% CI, 1.1-1.14).
“Heart failure often leads to hospitalizations, and it is two to three times more common in diabetic patients than in the general population,” Lind said during an oral session. “Poor glycemic control is a strong risk factor for hospitalization of HF in type 2 diabetes, whereas slight to moderately impaired glycemic control shows no strong risk relation.” – by Stacey L. Fisher
Disclosures: This research was supported by the Swedish Heart and Lung Foundation and the Swedish Research Council.
For more information:
- Lind M. Abstract #50. Presented at: The European Association for the Study of Diabetes 47th Annual Meeting; Sept. 12-16, 2011; Lisbon.
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