Ceramide-containing regimen improves diabetes mellitus-associated xerosis
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A ceramide-containing skin care regimen was associated with greater than 90% improvement and patient satisfaction in a cohort of individuals with diabetes mellitus-associated xerosis, according to a study.
Robert S. Kirsner, MD, PhD, chair of the department of dermatology and cutaneous surgery at University of Miami Miller School of Medicine, and Anneke Andriessen, PhD, of Radboud University Medical Center in Nijmegen, the Netherlands, noted that diabetes mellitus can commonly be found in the general population.
“Seventy percent of patients present with a cutaneous complication, including xerosis,” Kirsner and Andriessen wrote.
The researchers suggested that ceramide-containing (CER) skin care has shown efficacy as a “healthy skin barrier” in some patient populations.
In the international, multicenter, open-label cohort study, Kirsner and Andriessen accrued 528 patients aged 18 to 75 years with diabetes mellitus-associated xerosis from 19 countries. Type 2 diabetes was reported in 82.6% of the cohort.
Participants were treated twice daily for 1 month with a CER-containing cleanser and moisturizing cream. Screening assessments occurred between 30 and 0 days prior to baseline. After a baseline assessment at day 0, follow-up occurred 4 weeks later.
Patients were assessed using the Global Aesthetic Improvement Scale (GAIS) and the physician and subject-scored Dry Skin Classification Scale (DSCS). Other outcomes included patient-reported quality of life (QOL) and satisfaction scale with treatment outcomes, along with adverse events.
Results showed that 98.3% of participants met primary endpoint criteria as assessed by GAIS.
Statistically significant improvements were observed for all physician- and patient-reported DSCS scores at 4 weeks among patients using the CER-containing regimen (P < .001).
Other results from the 4-week assessment showed significant improvements in patient-reported QOL (P < .001). The researchers observed a 99.6% patient satisfaction rate for skin care outcomes and a 99.4% satisfaction rate for features of the CER-containing product.
At the end of the study, 91.5% of participants reported that they would continue to use the regimen.
There were no treatment-emergent adverse events reported.
“CER-containing cleanser and moisturizer were associated with statistically significant improvements in [diabetes mellitus]-associated xerosis, physician and subject scored severity, patient satisfaction and improved QOL,” the researchers concluded.
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