COVID-19 vaccination lowers all-cause mortality risk by 82% among patients with HF
Click Here to Manage Email Alerts
Key takeaways:
- Vaccinated patients with HF had an 82% lower risk for all-cause death than unvaccinated patients.
- Vaccinated patients were less likely to experience COVID-19 infection, CV events or HF hospitalization.
COVID-19 vaccination decreased the risk for CV events, hospitalization and death among patients with HF, according to a poster presented at the European Society of Cardiology’s Heart Failure 2024 meeting.
“Patients with heart failure should be vaccinated against COVID-19 to protect their health,” Kyeong-Hyeon Chun, MD, of the division of cardiology at National Health Insurance Service Ilsan Hospital in Goyang, South Korea, said in an ESC press release. “In this large study of patients with heart failure, COVID-19 vaccination was associated with a lower likelihood of contracting the infection, being admitted to hospital because of heart failure or dying from any cause during a 6-month period compared with remaining unvaccinated.”
The study included data from 651,127 adults (50% women; mean age, 69.5 years) with HF, of whom 538,434 (83%) had received at least two doses of a COVID-19 vaccine and 112,693 (17%) were considered unvaccinated, meaning they had received one dose or none.
The researchers performed a comparative analysis of 73,559 vaccinated patients and 73,559 unvaccinated patients matched based on age, sex, health conditions, income and residence.
Median follow-up was 6 months.
Patients who were vaccinated had a 13% lower risk for COVID-19 infection compared with unvaccinated patients (HR = 0.87; 95% CI, 0.69-0.98). Vaccinated patients also had lower risk for CV events like stroke (HR = 0.31; 95% CI, 0.29-0.33), MI (HR = 0.39; 95% CI, 0.3-0.53), myocarditis or pericarditis (HR = 0.53; 95% CI, 0.45-0.62) and venous thromboembolism (HR = 0.5; 95% CI, 0.48-0.54).
Fewer vaccinated patients were hospitalized for HF (n = 9,411 vs. 16,961) or experienced all-cause death (n = 5,328 vs. 25,273) than unvaccinated patients. The comparative analysis showed vaccinated patients had a 47% lower risk for HF hospitalization (HR = 0.53; 95% CI, 0.52-0.55) and an 82% lower risk for all-cause death (HR = 0.18; 95% CI, 0.17-0.18) compared with unvaccinated patients.
“This was the first analysis of COVID-19 vaccine effectiveness in a large population of heart failure patients, and the first to show benefit from vaccination,” Chun said in the release. “The study provides strong evidence to support vaccination in patients with heart failure. However, this evidence may not be applicable to all patients with heart failure, and the risks of vaccination should be considered in patients with unstable conditions.”
Reference:
- COVID-19 vaccine can help people with heart failure live longer. https://www.escardio.org/The-ESC/Press-Office/Press-releases/COVID-19-vaccine-can-help-people-with-heart-failure-live-longer. Published May 11, 2024. Accessed May 28, 2024.
Collapse
Chun KH, et al. Association between vaccination against COVID-19 and clinical outcomes in patients with heart failure: Using the Korean National Health Insurance Service database. Presented at: Heart Failure 2024; May 11-14, 2024; Lisbon, Portugal.
Read more about
Click Here to Manage Email Alerts