Poor control of CVD risk factors common in men with prostate cancer
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Men with prostate cancer are likely to have poor control of modifiable CV risk factors, according to study findings published in JACC: CardioOncology.
“Poor control of modifiable cardiovascular risk factors is common in men with prostate cancer, highlighting the large gap in care and the need for improved and novel interventions to optimize cardiovascular risk management in this population,” Harry Klimis, MBBS, PhD, clinical and research fellow at the Population Health Research Institute and department of medicine at McMaster University and Hamilton Health Sciences in Ontario, Canada, and colleagues wrote.
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In a prospective study of 2,811 men from the RADICAL-PC prospective cohort study diagnosed with prostate cancer between December 2015 and January 2022, the researchers collected demographics information and clinical factors from patient medical records to analyze the correlation between poor CV risk factor control and prostate cancer.
The researchers found that 23% of patients had preexisting CVD, with 98% having at least one poorly controlled CV risk factor — suboptimal LDL, current smoking, physical inactivity, suboptimal BP control or elevated waist-to-hip ratio, a measure of abdominal obesity.
The most common uncontrolled risk factor was abdominal obesity. Ninety-one percent of the patients had a waist-to-hip circumference in an unhealthy range.
In addition, 51% of patients had three or more CV risk factors that were poorly controlled, according to the researchers.
The researchers found that not taking a statin was associated with poor overall risk factor control (adjusted OR = 2.55; 95% CI, 2-3.26), as was physical frailty (aOR = 2.37; 95% CI, 1.51-3.71), need for BP drugs (aOR = 2.36; 95% CI, 1.84-3.03) and age (aOR per 10-year increase = 1.34; 95% CI, 1.14-1.59).
Of the participants with preexisting CVD, 74% were taking statins, whereas 41% of those without preexisting CVD but with high CVD risk were taking statins.
“Clinicians should routinely screen for cardiovascular risk factors in all men with prostate cancer and consider measures to prevent frailty, optimize BP, and initiate statin therapy in appropriate individuals as part of a comprehensive prostate cancer survivorship strategy,” Klimis and colleagues wrote.
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