Low vitamin D levels may be tied to HFpEF risk in Black Americans
Click Here to Manage Email Alerts
Low serum vitamin D levels were linked to left ventricular concentric remodeling and risk for HF, particularly HF with preserved ejection fraction, according to new data from the Jackson Heart Study.
“The prevalence of vitamin D3 deficiency is higher among Black Americans than in other race/ethnicity groups,” Daisuke Kamimura, MD, PhD, cardiologist and research scientist at the University of Mississippi Medical Center, and colleagues wrote in the Journal of Cardiac Failure. “We hypothesized that serum vitamin D3 levels are associated with LV concentric remodeling and incident HFpEF in Black Americans.”
The researchers analyzed 5,306 Black Americans from the Jackson Heart Study to determine the relationship between serum vitamin D3 levels, LV structure and function parameters determined via echocardiography and incident hospitalization for HF, whether it be HFpEF or HF with reduced ejection fraction.
After adjusting for confounders, the researchers determined that lower vitamin D3 levels were associated with greater relative wall thickness (beta for 1 standard deviation [SD] increase, –0.003; 95% CI, –0.005 to –0).
During a median follow-up of 11 years, 340 participants developed HF (57% of which were HFpEF), for a rate of 7.88 per 1,000 person-years.
After adjustment for conventional CV risk factors and prevalent CHD, higher levels of serum vitamin D3 were linked to lower risk for HF (HR per 1 SD increase = 0.88; 95% CI, 0.78-0.99), driven by HFpEF (HR per 1 SD increase = 0.84; 95% CI, 0.71-0.99), according to the researchers.
“To the best of our knowledge, the present study is the first study to examine the relationships between vitamin D levels and HFpEF hospitalization, particularly in Black Americans, who have greater rates of HF and are more likely to have vitamin D deficiency compared to Caucasians,” Kamimura and colleagues wrote. “The prevalence of comorbidities in HFpEF is high, and it has been suggested that inflammation may mediate the association between comorbidities and LV diastolic dysfunction in HFpEF patients.”
Previous studies were mixed as to whether vitamin D supplementation could help prevent HF, but they did not examine HFpEF specifically, the researchers wrote.
“Therefore, further investigation of the effectiveness of vitamin D3 supplementation on development of HFpEF is warranted,” they wrote.
Collapse
Click Here to Manage Email Alerts