‘Simple and economic’ tool: Triglyceride glucose index predicts HFpEF in hypertension
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The triglyceride glucose index, a novel marker of insulin resistance, strongly correlates with the occurrence of HF with preserved ejection fraction in adults with hypertension, according to an analysis of electronic medical records data.
“A growing body of studies have confirmed that triglyceride glucose index is related to the occurrence of cardiovascular and cerebrovascular diseases in patients with hypertension,” Li Ping Liao, MD, of the Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, China, and colleagues wrote in Clinical Cardiology. “In our study, logistic regression analyses indicated that after age, sex and baseline features were adjusted, E/e’, N-terminal pro-B type natriuretic peptide levels and triglyceride glucose index were independent risk factors for the incidence of HFpEF in patients with hypertension.”
Liao and colleagues analyzed EMR data from 559 patients with hypertension admitted to the inpatient ward of the of the Jiading Branch of Shanghai General Hospital from 2020 to 2021, including 273 patients with HFpEF (54.9% men). Mean age was 71 years. Researchers assessed cardiac function and ventricular structure index with echocardiography and used Pearson correlation analysis to identify the correlation of triglyceride glucose index with cardiac function and ventricular structure.
Compared with patients without HFpEF, those with HFpEF had a higher fasting plasma glucose, higher NT‐proBNP and triglyceride levels, a higher triglyceride glucose index, left atrial diameter, left ventricular mass index and E/e’ ratio. Those with HFpEF also had a higher systolic BP but lower E/A ratio compared with patients without HFpEF.
The triglyceride glucose index was correlated with LAD, LVEF, left ventricular mass index, average e, E/e’ and NT‐proBNP. In regression analysis, researchers found that triglyceride glucose index, E/e’ and NT‐proBNP were independent risk factors for HFpEF in adults with hypertension.
Compared with E/e’ and NT‐proBNP, the area under the receiver operating characteristic curve was the largest for triglyceride glucose index (0.778; 95% CI, 0.707-0.849).
“Triglyceride glucose index is a simple and economic indicator of insulin resistance, which is useful to help clinicians screen out the ‘high‐risk group’ prone to HFpEF in hypertensive patients early and can be routinely monitored during the management of patients,” the researchers wrote. “It is recommended to add the triglyceride glucose index to the routine evaluation model of hypertensive population.”
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