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Biologics/Immunotherapy News
On-demand sebetralstat effective for hereditary angioedema attacks in larynx
SAN DIEGO — Patients with hereditary angioedema whose attacks impacted their larynx experienced on-demand relief within 1.29 hours with oral sebetralstat, preventing potentially fatal outcomes, according to an abstract presented here.
Chronic rhinosinusitis with nasal polyps improves with tezepelumab
SAN DIEGO — Patients with chronic rhinosinusitis with nasal polyps saw improvements across all endpoints with tezepelumab, according to an abstract presented here.
Risk factors impact denials, wait times, discontinuations in biologic treatment for asthma
SAN DIEGO — Multiple risk factors were associated with denials and longer wait times for biologic treatment in moderate to severe asthma, as well as with discontinuations, according to a series of posters presented here.
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Eosinophilic granulomatosis with polyangiitis remission achieved with benralizumab
SAN DIEGO — Remission persisted through 104 weeks for most patients with eosinophilic granulomatosis with polyangiitis who used benralizumab, according to a poster presented here.
Twice-yearly depemokimab for asthma tolerated well as exacerbation rates fall
SAN DIEGO — Patients with asthma who used depemokimab tolerated treatment well while experiencing reductions in rates of clinically significant exacerbations, according to a poster abstract presented here.
Itch, urticaria activity improve with dupilumab after refractory antihistamine treatment
SAN DIEGO — Patients with chronic spontaneous urticaria that was not controlled with H1 antihistamines experienced improvements in itch and urticaria activity with dupilumab, according to a poster presented here.
FDA approves omalizumab biosimilar Omlyclo
The FDA approved Celltrion’s omalizumab biosimilar, Omlyclo, for the treatment of multiple conditions including asthma and food allergy, according to an agency press release.
Response to peanut patch treatment increases through 60 months
SAN DIEGO — Percentages of children with peanut allergy who responded to treatment with the VP250 VIASKIN Peanut patch from DBV Technologies increased from 12 months through 60 months, according to an abstract presented here.
Patients introduce allergens into their diets after using omalizumab
SAN DIEGO — Patients with multiple food allergies introduced allergens into their diets after using omalizumab, researchers reported at the 2025 American Academy of Allergy, Asthma & Immunology/World Allergy Organization Joint Congress.
Chart review supports expansion of subcutaneous immunotherapy, oral food challenges
SAN DIEGO — A retrospective chart review of patients with allergy who participated in subcutaneous immunotherapy and oral food challenges suggested that these therapies should be expanded, according to a pair of posters presented here.
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