Tofacitinib

LAS VEGAS – Physicians should remember there are many points to consider when selecting the right treatment for patients with ulcerative colitis, according to a presenter at the ACG Annual Scientific Meeting.

Patients with rheumatoid arthritis who achieved greater response with tofacitinib do so regardless of whether methotrexate was added to therapy or not, according to data published in Arthritis Research & Therapy.

The FDA has called for additional warning labels on janus kinase inhibitors after a safety review found this class of medications was associated with an excess risk for serious heart-related events, cancer, blood clots and death.

Corticosteroid and tofacitinib use in patients with inflammatory bowel disease correlated with increased total cholesterol levels, according to research published in Alimentary Pharmacology and Therapeutics.

The FDA authorized the emergency use of tocilizumab for certain hospitalized patients with COVID-19. This marks the fourth monoclonal antibody authorized during the pandemic.

Researchers have identified five distinct phenotypic subgroups based on disease trajectory among methotrexate-naïve patients with rheumatoid arthritis receiving tofacitinib, according to data published in Arthritis Care & Research.

Treatment with tofacitinib led to a lower risk for death or respiratory failure through day 28, compared with placebo, in patients hospitalized with COVID-19 pneumonia, according to data published in The New England Journal of Medicine.

Tofacitinib 2 mg twice daily demonstrated “significantly greater” efficacy than placebo in adults with ankylosing spondylitis, according to researchers writing in the Annals of the Rheumatic Diseases.

Tofacitinib treatment in patients with sarcoidosis with cutaneous involvement delivered significant improvements, according to a study presented at AAD VMX 2021.

Simultaneous use of biologic agents in combination or with Xeljanz may be a viable treatment option for highly selected, refractory patients with inflammatory bowel disease, according to study results.